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GHActive

Will Guardant360 ADLT FDA submission occur by year-end 2026?

Resolves January 15, 2027(281d)
IG: 0.48

Current Prediction

60%
Likely Yes
Model Agreement94%
Predictions9 runs
Last UpdatedApril 8, 2026

Why This Question Matters

ADLT pricing for Guardant360 would improve unit economics starting 2027. FDA submission status is a key milestone.

REGULATORY_EXPOSUREUNIT_ECONOMICS

Prediction Distribution

0%25%50%75%100%
opus
sonnet
haiku
Range: 58%62%Aggregate: 60%
Individual Predictions(9 runs)
opusRun 1
62%

FDA submission is largely within company control unlike guideline inclusion. Management has indicated it is pending. Strong financial incentive to submit for improved reimbursement.

Within company controlManagement indicated pendingFinancial incentive
opusRun 2
58%

Submission requires completed clinical and analytical validation packages. These take time but are well-understood processes for GH. Some risk of delays in package preparation.

Validation packages neededWell-understood processPreparation delay risk
opusRun 3
60%

Management's execution track record supports confidence. ADLT submission is a company-controlled milestone with clear financial benefits.

Execution track recordCompany-controlledClear financial benefits
sonnetRun 1
60%

Company-controlled submission with strong incentive. Regulatory submissions have more predictable timelines than external guideline processes.

Company-controlledStrong incentivePredictable timeline
sonnetRun 2
58%

FDA submission preparation can encounter unexpected delays. But the financial incentive is strong and management has been executing well.

Preparation delays possibleFinancial incentiveGood execution
sonnetRun 3
62%

High probability for a company-controlled milestone. Management track record and financial incentive align.

Company-controlledTrack recordAligned incentives
haikuRun 1
60%

Company-controlled milestone with good execution history. ~60%.

Company-controlledGood history60%
haikuRun 2
58%

Strong incentive but preparation timelines can slip. ~58%.

Strong incentiveTimeline risk58%
haikuRun 3
60%

Base rate for planned submissions plus management track record. ~60%.

Base rateTrack record60%

Resolution Criteria

Resolves YES if FDA submission for ADLT designation occurs by December 31, 2026. Resolves NO if not submitted.

Resolution Source

FDA database, Guardant Health press releases

Source Trigger

ADLT pricing for Guardant360 via FDA submission pending; pricing impact starting 2027

regulatory-readerREGULATORY_EXPOSUREMEDIUM
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